Promethazine is metabolized by the liver to several different compounds; the sulfoxides of promethazine and N-demethylpromethazine are definitely the predominant metabolites showing in the urine.

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Hold an index of each of the goods you employ (including prescription/nonprescription medication and herbal products) and share it using your medical doctor and pharmacist. Usually do not start, halt, or alter the dosage of any medicines without the need of your medical professional's acceptance.

This medication might trigger damage and death whether it is taken by other adults, children, or Animals. It is important to get rid of the medication when you no longer require it or it really is expired. You are able to do this in two strategies:

Promethazine HCl and Codeine Phosphate Oral Resolution is indicated for that momentary reduction of coughs and higher respiratory indications connected to allergy or maybe the popular chilly in people 18 several years of age and older.

Do not forget that this medication continues to be prescribed mainly because your doctor has judged the benefit to you is greater than the potential risk of Unwanted side effects. A lot of people working with this medication would not have serious side effects.

Codeine Codeine is surely an opioid agonist rather selective with the mu-opioid receptor, but by using a A great deal weaker affinity than morphine. The analgesic and antitussive Houses of codeine happen to be speculated to come from its conversion to morphine.

The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people below 6 decades of age, since the combination may perhaps induce fatal respiratory depression During this age populace.

The following adverse reactions happen to be determined all through medical scientific studies, within the literature, or through put up-acceptance use of codeine and/or promethazine.

Nursing moms getting codeine can also have bigger morphine stages of their breast milk When they are extremely-quick metabolizers. These increased amounts of morphine in breast milk may perhaps lead to lifetime-threatening or fatal Unintended effects in nursing infants. Instruct nursing moms to watch for indications of morphine toxicity in their infants such as improved sleepiness (more than usual), difficulty breastfeeding, breathing complications, or limpness.

Promethazine is actually a phenothiazine derivative which differs structurally with the antipsychotic phenothiazines because of the presence of a branched side chain and no ring substitution.

For those who have soreness, you do have a professional medical purpose to consider suffering medication. Your care team will inform you exactly how much medication to acquire. If your treatment workforce needs you to stop the medication, the dose is going to be bit Promethazine codeine syrup by bit decreased after some time to prevent any side effects.

Codeine can result in really serious undesired effects if taken by Grownups, children, or Animals who're not utilized to sturdy narcotic agony medicines. You should definitely retail outlet the drugs in a safe and protected location to circumvent Many others from finding it. Drop off any unused narcotic medicine at a drug take-back again site straight away.

It is critical which you fully grasp the rules of the Opioid Analgesic REMS method to prevent addiction, abuse, and misuse of codeine. This medicine should also have a Medication Tutorial. Go through and comply with these instructions very carefully. Read through it once more every time you refill your prescription in case There may be new information and facts. Inquire your medical professional For those who have any concerns.